Mechanotransduction: Getting Morphogenesis Down Pat
نویسنده
چکیده
Embryonic morphogenesis requires the coordination of forces across multiple tissues and their associated extracellular matrices. A new study reports a mechanical feedback loop in the Caenorhabditis elegans embryo between muscle and epidermis that may provide a model for understanding how tissues coordinate morphogenetic events in the embryo.
منابع مشابه
Rac GTPase signaling in mechanotransduction during embryonic morphogenesis
How cells sense and respond to mechanical forces is attracting considerable attention. We recently demonstrated that mechanical tension originating from one tissue strongly influences the differentiation and morphogenesis of another tissue during C. elegans embryogenesis (Nature 471:99-103). Specifically, we found that the repeated contractions of muscle cells stimulate a signaling cascade invo...
متن کاملklf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis
The heartbeat and blood flow signal to endocardial cell progenitors through mechanosensitive proteins that modulate the genetic program controlling heart valve morphogenesis. To date, the mechanism by which mechanical forces coordinate tissue morphogenesis is poorly understood. Here we use high-resolution imaging to uncover the coordinated cell behaviours leading to heart valve formation. We fi...
متن کاملMechanosensitive control of plant growth: bearing the load, sensing, transducing, and responding
As land plants grow and develop, they encounter complex mechanical challenges, especially from winds and turgor pressure. Mechanosensitive control over growth and morphogenesis is an adaptive trait, reducing the risks of breakage or explosion. This control has been mostly studied through experiments with artificial mechanical loads, often focusing on cellular or molecular mechanotransduction pa...
متن کاملS21-01. Tension and mechanotransduction in embryonic morphogenesis
We know a great deal about the mechanisms controlling common cellular processes, but still do not understand how cells communicate to ensure that they stretch in a coordinate manner. For instance, C. elegans embryonic morphogenesis relies on cell shape changes within the epidermis and on epidermis-muscles interactions. I will illustrate the importance of forces and tension during morphogenesis ...
متن کاملThe Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission
The post-translational addition of C-16 long chain fatty acids to protein cysteine residues is catalysed by palmitoyl-S-acyl-transferases (PAT) and affects the affinity of a modified protein for membranes and therefore its subcellular localisation. In apicomplexan parasites this reversible protein modification regulates numerous biological processes and specifically affects cell motility, and i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 21 شماره
صفحات -
تاریخ انتشار 2011